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At the level of gene expression, analyses using the Connectivity Map (cMap) from the Broad Institute demonstrate that GHK influences the expression of over 4,000 human genes

Case classification breakdown was as follows: 7/13 (53.8%) cases were SJS, 0/13 (0%) cases were SJS/TEN overlap, and 6/13 (46.2%) cases were TEN

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Ferroptosis is negatively regulated by the enzymatic activity of GPX4, and increasing attention to possible ways of inhibiting this cell death modality are needed ( In order to test if our new activator could have a beneficial effect in the context of inhibiting cell death, we evaluated compound 102 for its ability to prevent erastin-induced ferroptosis